| Character | Played By | Apeared | |
| Louise Salisbury | Caroline Strong | ||
| Melanie Say | Be-friend Zoe while she was in the staying psychatric hospital. | Kelli Hollis | Featured week of 29th July - 2 August 2002 and 5-7 August 2002, 11 November 2002 |
| Abraham Scarsdale | Bill Dean | ||
| Dr Clare Scott | Joanna Tope | ||
| Sir Gerald Scott | Kenneth Benda | ||
| Mavis Scott | Beryl Cook | ||
| Sedden | Geoffery Russel | ||
| Hilda Semple | Liz Smith | ||
| Dudley Seward | James Tomlinson | ||
| Dr Sharma | Rashid Karapiet | ||
| Sita Sharma | Mamta Kash | ||
|
Dolores Sharp
|
|
Samantha Hurst | (March 1994 - circa December 1995) |
| Mrs Sharp | Shirley Vaughn | ||
| Robert Sharp | Bernard Kay | ||
| Ted Sharp | Andy Rashleigh | ||
| Bill Shepherd | (social worker who is helping Paddy and Emily adopt) | John Griffin | August 2002 - |
| Tom Shepherd | Steve Evets | (1998-1999) | |
| Shirly | Frances Goodall | ||
|
Shop Assistant
|
Emma Phillips | 23 January 2003 | |
| Doreen Shuttleworth | Sandra Gough | ||
| Earnie Shuttleworth | John Comer/Peter Scofield | ||
| Sister | Sue Warhurst | (March 1998) | |
| Julian Simondsbury | James Hoare | ||
| Derek Simpson | Gary Cooper | ||
|
Mr Skip
|
Dave Dutton | 29 October 2002 - November 2002 | |
| Miss Skipdale Breweries | Jayne Ashbourne | ||
| Paul Slater | Eric Coudrill | Featured week of 14 October - 18 October 2002 | |
| Ronnie Slater | Ian Tompson | ||
| Bert Sleightholme | Harry Beety | ||
| D.I. Spalding |
|
Davyd Harries | (33 episodes 1998-1999) |
| Davy Squires | Paul Alexander | ||
| Frankie Smith |
Zoe Tate's lover
 |
Gina Aris | (32 episodes 1999) |
| Frankie Smith | Madeleine Bowyer | (4 January 2000 - 2000) | |
| Toddy Snell | Ted Morris | ||
| Jo Steadman | Julie Peasgood | (1997) | |
|
Nurse Chelna Stevenson |
Rina Hahoney | 11th July 2003, featured w/b 14th July 2003 also | |
|
|
|||
| Miss Strickland | Alex Hall | 1997?, (9 episodes 1999) , 2000 -10 September 2001 | |
| Stan | Peter Ellis | ||
| George Starkey | James Noble | ||
| Steven | Tim Healy | ||
| Alan Stevenson | Peter Ivatts | ||
| Annette Stevenson | Wenda Brown | ||
| John Stokes | Stephen Mallatratt | ||
| Tricia Stokes | Sheree Murphy | ||
| Lucy Stubbs | Adrienne Franks | ||
| Clare Sutcliffe | Sara Griffiths | ||
| Mr Swannick | Fred Gaunt | ||
| Mrs Swannick | Doreen Kay | ||
| Sykes | Stuart Goddard |
